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A naturally monomeric infrared fluorescent protein for protein labeling in vivo

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521985/
No data is associated with this publication.
Abstract

Infrared fluorescent proteins (IFPs) provide an additional color to GFP and its homologs in protein labeling. Drawing on structural analysis of the dimer interface, we identified a bacteriophytochrome in the sequence database that is monomeric in truncated form and engineered it into a naturally monomeric IFP (mIFP). We demonstrate that mIFP correctly labels proteins in live cells, Drosophila and zebrafish. It should be useful in molecular, cell and developmental biology.

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