UC Santa Cruz
Regulation of the X chromosomes in Caenorhabditis elegans.
- Author(s): Strome, Susan
- Kelly, William G
- Ercan, Sevinc
- Lieb, Jason D
- et al.
Published Web Locationhttps://doi.org/10.1101/cshperspect.a018366
Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.