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Open Access Publications from the University of California

Regulation of the X chromosomes in Caenorhabditis elegans.

  • Author(s): Strome, Susan
  • Kelly, William G
  • Ercan, Sevinc
  • Lieb, Jason D
  • et al.

Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.

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