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Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression.
Published Web Location
http://europepmc.org/articles/PMC4379087?pdf=renderNo data is associated with this publication.
Abstract
HoxA5 is expressed in quiescent endothelial cells (EC), but absent in activated angiogenic EC. To examine the efficacy of targeting HoxA5 therapeutically to quell pathologic or tumor angiogenesis, we generated an inducible, transgenic mouse model of sustai
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