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Effectiveness of nonadjuvanted monovalent influenza A(H1N1)pdm09 vaccines for preventing reverse transcription polymerase chain reaction-confirmed pandemic influenza hospitalizations: case-control study of children and adults at 10 US influenza surveillance network sites.

  • Author(s): Thompson, Mark G
  • Sokolow, Leslie Z
  • Almendares, Olivia
  • Openo, Kyle
  • Farley, Monica M
  • Meek, James
  • Ray, Julie
  • Kirley, Pamala Daily
  • Reingold, Arthur
  • Aragon, Deborah
  • Hancock, Emily
  • Baumbach, Joan
  • Schaffner, William
  • Thomas, Ann
  • Lynfield, Ruth
  • Ryan, Pat
  • Monroe, Maya
  • Cheng, Po-Yung
  • Fry, Alicia M
  • Shay, David K
  • et al.
Abstract

During 2009-2010, we examined 217 patients hospitalized with laboratory-confirmed pandemic influenza in 9 Influenza Hospitalization Surveillance Network sites and 413 age- and community-matched controls and found that a single dose of monovalent nonadjuvanted influenza A(H1N1)pdm09 vaccine was 50% (95% confidence interval, 13%-71%) effective in preventing hospitalization associated with A(H1N1)pdm09 virus infection.

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