Templating Antiviral RNAi in Insects.
- Author(s): Han, Yanhong;
- Wu, Qingfa;
- Ding, Shou-Wei
- et al.
Published Web Locationhttps://doi.org/10.1016/j.chom.2018.02.010
Virus-specific small interfering RNAs (siRNAs) are a central component of antiviral responses in insects. In this issue of Cell Host & Microbe, Poirier et al. (2018) demonstrate that virus-infected flies and mosquitoes produce virus-derived extrachromosomal circular DNAs that serve as a template for the biogenesis of antiviral siRNAs.