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Templating Antiviral RNAi in Insects
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https://doi.org/10.1016/j.chom.2018.02.010Abstract
Virus-specific small interfering RNAs (siRNAs) are a central component of antiviral responses in insects. In this issue of Cell Host & Microbe, Poirier et al. (2018) demonstrate that virus-infected flies and mosquitoes produce virus-derived extrachromosomal circular DNAs that serve as a template for the biogenesis of antiviral siRNAs.
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