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Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.

  • Author(s): Morey, Robert
  • Laurent, Louise C
  • et al.
Abstract

Female mouse embryonic stem cells (mESCs) contain two active X chromosomes, with one undergoing random inactivation upon differentiation. Schulz et al. (2014) now demonstrate that the presence of two active X chromosomes in mESCs prevents exit from pluripotency by blocking MAPK signaling, ensuring synchronization between X chromosome dosage compensation and development.

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