Skip to main content
Open Access Publications from the University of California

Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.

  • Author(s): Morey, Robert
  • Laurent, Louise C
  • et al.

Female mouse embryonic stem cells (mESCs) contain two active X chromosomes, with one undergoing random inactivation upon differentiation. Schulz et al. (2014) now demonstrate that the presence of two active X chromosomes in mESCs prevents exit from pluripotency by blocking MAPK signaling, ensuring synchronization between X chromosome dosage compensation and development.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View