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Mission CaMKIIγ: Shuttle Calmodulin from Membrane to Nucleus
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https://doi.org/10.1016/j.cell.2014.09.023Abstract
Neuronal plasticity depends on plasma membrane Ca(2+) influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca(2+) initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca(2+) channels to the nucleus.
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