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Open Access Publications from the University of California

Synaptic proteins : Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide

  • Author(s): Kelly, PT
  • Cotman, CW
  • et al.

The major proteins in isolated synaptic junctions (SJs) and postsynaptic densities (PSDs) have been compared to actin, tubulin, and the major neurofilament (NF) protein by two-dimensional gel electrophoresis and tryptic peptide map analysis. These studies show: (a) tubulin is present in SJ and PSD fractions and is identical to cytoplasmic tubulin, (b) actin in these fractions is very similar to the γ- and β-actin found predominantly in nonmuscle cells, and (c) the major PSD protein is distinct from all other known fibrous proteins. © 1978, Rockefeller University Press., All rights reserved.

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