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Activation Associated ERK1/2 Signaling Impairments in CD8+ T Cells Co-Localize with Blunted Polyclonal and HIV-1 Specific Effector Functions in Early Untreated HIV-1 Infection
- Author(s): Hecht, Frederick
- Pilcher, Christopher
- Crawford, TQ
- Hecht, FM
- Pilcher, CD
- Ndhlovu, LC
- Barbour, JD
- et al.
Published Web Location
http://europepmc.org/articles/PMC3797111?pdf=renderNo data is associated with this publication.
Abstract
We recently observed that a large proportion of activated (CD38+HLA-DR+) CD8+ T cells from recently HIV-1-infected adults are refractory to phosphorylation of ERK1/2 kinases (p-ERK1/2-refractory). Given that the ERK1/2 pathway mediates intracellular signal
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