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Activation Associated ERK1/2 Signaling Impairments in CD8+ T Cells Co-Localize with Blunted Polyclonal and HIV-1 Specific Effector Functions in Early Untreated HIV-1 Infection

  • Author(s): Hecht, Frederick
  • Pilcher, Christopher
  • Crawford, TQ
  • Hecht, FM
  • Pilcher, CD
  • Ndhlovu, LC
  • Barbour, JD
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3797111?pdf=render
No data is associated with this publication.
Abstract

We recently observed that a large proportion of activated (CD38+HLA-DR+) CD8+ T cells from recently HIV-1-infected adults are refractory to phosphorylation of ERK1/2 kinases (p-ERK1/2-refractory). Given that the ERK1/2 pathway mediates intracellular signal

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