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The molecular logic of endocannabinoid signalling.

  • Author(s): Piomelli, Daniele
  • et al.

Published Web Location

https://doi.org/10.1038/nrn1247Creative Commons 'BY' version 4.0 license
Abstract

The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana (Cannabis). They are made on demand through cleavage of membrane precursors and are involved in various short-range signalling processes. In the brain, they combine with CB1 cannabinoid receptors on axon terminals to regulate ion channel activity and neurotransmitter release. Their ability to modulate synaptic efficacy has a wide range of functional consequences and provides unique therapeutic possibilities. © 2003, Nature Publishing Group. All rights reserved.

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