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Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model.

  • Author(s): Yano, Shuya
  • Takehara, Kiyoto
  • Miwa, Shinji
  • Kishimoto, Hiroyuki
  • Hiroshima, Yukihiko
  • Murakami, Takashi
  • Urata, Yasuo
  • Kagawa, Shunsuke
  • Bouvet, Michael
  • Fujiwara, Toshiyoshi
  • Hoffman, Robert M
  • et al.
Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in situ in an orthotopic mouse model enabling successful FGS. OBP-401-GFP-labeled liver metastasis resulted in complete resection with FGS, in contrast, conventional bright-light surgery (BLS) did not result in complete resection of the metastasis. OBP-401-FGS reduced the recurrence rate and prolonged over-all survival compared with BLS. In conclusion, adenovirus OBP-401 is a powerful tool to label liver metastasis in situ with GFP which enables its complete resection, not possible with conventional BLS.

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