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Open Access Publications from the University of California

tsRNAs: new players in mammalian retrotransposon control.

  • Author(s): Zhang, Yunfang
  • Shi, Junchao
  • Chen, Qi
  • et al.

A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may defend itself from retrotransposon invasion during epigenetic reprogramming.

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