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Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
- Camarda, Roman;
- Zhou, Alicia Y;
- Kohnz, Rebecca A;
- Balakrishnan, Sanjeev;
- Mahieu, Celine;
- Anderton, Brittany;
- Eyob, Henok;
- Kajimura, Shingo;
- Tward, Aaron;
- Krings, Gregor;
- Nomura, Daniel K;
- Goga, Andrei
Published Web Location
https://doi.org/10.1038/nm.4055Abstract
In the triple-negative subtype of breast cancer, for which treatment options are limited, overexpression of the MYC oncoprotein is associated with increased sensitivity to growth inhibition by fatty acid oxidation inhibitors, thus pointing to a new therapeutic strategy.
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