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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
- Author(s): Renslo, Adam;
- Arkin, Michelle;
- Heise, CE;
- Murray, J;
- Augustyn, KE;
- Bravo, B;
- Chugha, P;
- Cohen, F;
- Giannetti, AM;
- Gibbons, P;
- Hannoush, RN;
- Hearn, BR
- et al.
Published Web Location
http://europepmc.org/articles/PMC3515450?pdf=renderNo data is associated with this publication.
Abstract
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase-6 tha
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