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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
- Author(s): Renslo, Adam
- Arkin, Michelle
- Heise, CE
- Murray, J
- Augustyn, KE
- Bravo, B
- Chugha, P
- Cohen, F
- Giannetti, AM
- Gibbons, P
- Hannoush, RN
- Hearn, BR
- et al.
Published Web Location
http://europepmc.org/articles/PMC3515450?pdf=renderNo data is associated with this publication.
Abstract
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase-6 tha
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