Skip to main content
Open Access Publications from the University of California

Asymmetric synthesis of α-branched amines via Rh(III)-catalyzed C-H bond functionalization.

  • Author(s): Wangweerawong, Apiwat;
  • Bergman, Robert G;
  • Ellman, Jonathan A
  • et al.

Published Web Location

The first asymmetric intermolecular addition of non-acidic C-H bonds to imines is reported. The use of the activating N-perfluorobutanesulfinyl imine substituent is essential for achieving sufficient reactivity and provides outstanding diastereoselectivity (>98:2 dr). Straightforward removal of the sulfinyl group with HCl yields the highly enantiomerically enriched amine hydrochlorides.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View