Skip to main content
eScholarship
Open Access Publications from the University of California

Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract.

  • Author(s): Khan, Shahzada
  • Lew, Irene
  • Wu, Frank
  • Fritts, Linda
  • Fontaine, Krystal A
  • Tomar, Sakshi
  • Trapecar, Martin
  • Shehata, Hesham M
  • Ott, Melanie
  • Miller, Christopher J
  • Sanjabi, Shomyseh
  • et al.

Published Web Location

https://www.nature.com/articles/s41467-019-12371-7
No data is associated with this publication.
Abstract

Innate immune responses to Zika virus (ZIKV) are dampened in the lower female reproductive tract (LFRT) compared to other tissues, but the mechanism that underlies this vulnerability is poorly understood. Using tissues from uninfected and vaginally ZIKV-infected macaques and mice, we show that low basal expression of RNA-sensing pattern recognition receptors (PRRs), or their co-receptors, in the LFRT contributes to high viral replication in this tissue. In the LFRT, ZIKV sensing provides limited protection against viral replication, and the sensors are also minimally induced after vaginal infection. While IFNα/β receptor signaling offers minimal protection in the LFRT, it is required to prevent dissemination of ZIKV to other tissues, including the upper FRT. Our findings support a role for RNA-sensing PRRs in the dampened innate immunity against ZIKV in the LFRT compared to other tissues and underlie potential implications for systemic dissemination upon heterosexual transmission of ZIKV in women.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item