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Open Access Publications from the University of California

Administration of Nebulized Ketamine for Managing Acute Pain in the Emergency Department: A Case Series

  • Author(s): Drapkin, Jefferson
  • Masoudi, Aidin
  • Butt, Mahlaqa
  • Hossain, Rukhsana
  • Likourezos, Antonios
  • Motov, Sergey
  • et al.

Ketamine administration in sub-dissociative doses in the emergency department (ED) results in effective pain relief in patients with acute traumatic and non-traumatic pain, chronic pain, and opioid-tolerant pain. This case series describes five adult ED patients who received nebulized ketamine for predominantly acute traumatic pain. Three patients received nebulized ketamine at 1.5 milligrams per kilogram (mg /kg) dose, one patient at 0.75 mg/kg, and one patient at 1 mg/kg. All five patients experienced a decrease in pain from the baseline up to 120 minutes. The inhalation route of ketamine delivery via breath-actuated nebulizer may have utility for managing pain in the ED.

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