Skip to main content
eScholarship
Open Access Publications from the University of California

Variation in NF-κB signaling pathways and survival in invasive epithelial ovarian cancer.

  • Author(s): Block, Matthew S
  • Charbonneau, Bridget
  • Vierkant, Robert A
  • Fogarty, Zachary
  • Bamlet, William R
  • Pharoah, Paul DP
  • Georgia Chenevix-Trench
  • for AOCS
  • /ACS Group
  • Rossing, Mary Anne
  • Cramer, Daniel
  • Pearce, Celeste Leigh
  • Schildkraut, Joellen
  • Menon, Usha
  • Kjaer, Susanne K
  • Levine, Douglas A
  • Gronwald, Jacek
  • Culver, Hoda Anton
  • Whittemore, Alice S
  • Karlan, Beth Y
  • Lambrechts, Diether
  • Wentzensen, Nicolas
  • Kupryjanczyk, Jolanta
  • Chang-Claude, Jenny
  • Bandera, Elisa V
  • Hogdall, Estrid
  • Heitz, Florian
  • Kaye, Stanley B
  • Fasching, Peter A
  • Campbell, Ian
  • Goodman, Marc T
  • Pejovic, Tanja
  • Bean, Yukie T
  • Hays, Laura E
  • Lurie, Galina
  • Eccles, Diana
  • Hein, Alexander
  • Beckmann, Matthias W
  • Ekici, Arif B
  • Paul, James
  • Brown, Robert
  • Flanagan, James M
  • Harter, Philipp
  • du Bois, Andreas
  • Schwaab, Ira
  • Hogdall, Claus K
  • Lundvall, Lene
  • Olson, Sara H
  • Orlow, Irene
  • Paddock, Lisa E
  • Rudolph, Anja
  • Eilber, Ursula
  • Dansonka-Mieszkowska, Agnieszka
  • Rzepecka, Iwona K
  • Ziolkowska-Seta, Izabela
  • Brinton, Louise A
  • Yang, Hannah
  • Garcia-Closas, Montserrat
  • Despierre, Evelyn
  • Lambrechts, Sandrina
  • Vergote, Ignace
  • Walsh, Christine S
  • Lester, Jenny
  • Sieh, Weiva
  • McGuire, Valerie
  • Rothstein, Joseph H
  • Ziogas, Argyrios
  • Lubiński, Jan
  • Cybulski, Cezary
  • Menkiszak, Janusz
  • Jensen, Allan
  • Gayther, Simon A
  • Ramus, Susan J
  • Gentry-Maharaj, Aleksandra
  • Berchuck, Andrew
  • Wu, Anna H
  • Pike, Malcolm C
  • Van Den Berg, David
  • Terry, Kathryn L
  • Vitonis, Allison F
  • Ramirez, Starr M
  • Rider, David N
  • Knutson, Keith L
  • Sellers, Thomas A
  • Phelan, Catherine M
  • Doherty, Jennifer A
  • Johnatty, Sharon E
  • deFazio, Anna
  • Song, Honglin
  • Tyrer, Jonathan
  • Kalli, Kimberly R
  • Fridley, Brooke L
  • Cunningham, Julie M
  • Goode, Ellen L
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082406
No data is associated with this publication.
Abstract

Survival in epithelial ovarian cancer (EOC) is influenced by the host immune response, yet the key genetic determinants of inflammation and immunity that affect prognosis are not known. The nuclear factor-κB (NF-κB) transcription factor family plays an important role in many immune and inflammatory responses, including the response to cancer. We studied common inherited variation in 210 genes in the NF-κB family in 10,084 patients with invasive EOC (5,248 high-grade serous, 1,452 endometrioid, 795 clear cell, and 661 mucinous) from the Ovarian Cancer Association Consortium. Associations between genotype and overall survival were assessed using Cox regression for all patients and by major histology, adjusting for known prognostic factors and correcting for multiple testing (threshold for statistical significance, P < 2.5 × 10(-5)). Results were statistically significant when assessed for patients of a single histology. Key associations were with caspase recruitment domain family, member 11 (CARD11) rs41324349 in patients with mucinous EOC [HR, 1.82; 95% confidence interval (CI), 1.41-2.35; P = 4.13 × 10(-6)] and tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) rs7501462 in patients with endometrioid EOC (HR, 0.68; 95% CI, 0.56-0.82; P = 2.33 × 10(-5)). Other associations of note included TNF receptor-associated factor 2 (TRAF2) rs17250239 in patients with high-grade serous EOC (HR, 0.84; 95% CI, 0.77-0.92; P = 6.49 × 10(-5)) and phospholipase C, gamma 1 (PLCG1) rs11696662 in patients with clear cell EOC (HR, 0.43; 95% CI, 0.26-0.73; P = 4.56 × 10(-4)). These associations highlight the potential importance of genes associated with host inflammation and immunity in modulating clinical outcomes in distinct EOC histologies.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item