UC Davis

A table-top microdevice was used to produce flavopiridol-loaded ultrasmall particles for pulmonary delivery to reduce pulmonary fibrosis and inflammation. Microparticles were image with the help of scanning electron microscopy to visualize their structure. The Loading capacity and encapsulation efficiency of flavopiridol in the microparticles were determine using a UV-Visible spectrophotometer. Commercial microfluidic piezo devices with different orifice diameter were optimized to get the preferred inhalable particle morphology. Optimized microparticles were subject to aerodynamic performance testing and moisture content analysis. The stability of microparticles were perform for up to 24 weeks. A high-speed camera with a long working distance lens was mounted to visualize the droplets size formed by a microfluidic piezo device. Synthesis parameters were optimized to produce microparticles, whose morphology, size, physio-chemical properties, aerodynamic performance, moisture content and release profiles met the criteria for inhalation.