Elimination of Von Hippel-Lindau Function Perturbs Pancreas Endocrine Homeostasis in Mice
- Author(s): Hebrok, Matthias;
- Puri, S;
- García-Núñez, A;
- Cano, DA
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3748057?pdf=render
Mutations in the human homolog of the Vhlh gene [encoding the von-Hippel Lindau (VHL) protein] lead to tumor development. In mice, depletion of Vhlh in pancreatic ß-cells causes perturbed glucose homeostasis, but the role of this gene in other pancreatic c