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Elimination of Von Hippel-Lindau Function Perturbs Pancreas Endocrine Homeostasis in Mice

  • Author(s): Hebrok, Matthias
  • Puri, S
  • García-Núñez, A
  • Cano, DA
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3748057?pdf=render
No data is associated with this publication.
Abstract

Mutations in the human homolog of the Vhlh gene [encoding the von-Hippel Lindau (VHL) protein] lead to tumor development. In mice, depletion of Vhlh in pancreatic ß-cells causes perturbed glucose homeostasis, but the role of this gene in other pancreatic c

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