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Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
- Jun, Gyungah R;
- Chung, Jaeyoon;
- Mez, Jesse;
- Barber, Robert;
- Beecham, Gary W;
- Bennett, David A;
- Buxbaum, Joseph D;
- Byrd, Goldie S;
- Carrasquillo, Minerva M;
- Crane, Paul K;
- Cruchaga, Carlos;
- De Jager, Philip;
- Ertekin‐Taner, Nilufer;
- Evans, Denis;
- Fallin, M Danielle;
- Foroud, Tatiana M;
- Friedland, Robert P;
- Goate, Alison M;
- Graff‐Radford, Neill R;
- Hendrie, Hugh;
- Hall, Kathleen S;
- Hamilton‐Nelson, Kara L;
- Inzelberg, Rivka;
- Kamboh, M Ilyas;
- Kauwe, John SK;
- Kukull, Walter A;
- Kunkle, Brian W;
- Kuwano, Ryozo;
- Larson, Eric B;
- Logue, Mark W;
- Manly, Jennifer J;
- Martin, Eden R;
- Montine, Thomas J;
- Mukherjee, Shubhabrata;
- Naj, Adam;
- Reiman, Eric M;
- Reitz, Christiane;
- Sherva, Richard;
- St. George‐Hyslop, Peter H;
- Thornton, Timothy;
- Younkin, Steven G;
- Vardarajan, Badri N;
- Wang, Li‐San;
- Wendlund, Jens R;
- Winslow, Ashley R;
- Adams, Perrie M;
- Albert, Marilyn S;
- Albin, Roger L;
- Apostolova, Liana G;
- Arnold, Steven E;
- Asthana, Sanjay;
- Atwood, Craig S;
- Barmada, Michjael M;
- Barnes, Lisa L;
- Beach, Thomas G;
- Becker, James T;
- Bigio, Eileen H;
- Bird, Thomas D;
- Blacker, Deborah;
- Boeve, Bradley F;
- Bowen, James D;
- Boxer, Adam;
- Burke, James R;
- Cairns, Nigel J;
- Cao, Chuanhai;
- Carlson, Chris S;
- Carlsson, Cynthia M;
- Carney, Regina M;
- Carrasquillo, Minerva M;
- Carroll, Steven L;
- Chui, Helena C;
- Clark, David G;
- Corneveaux, Jason;
- Cribbs, David H;
- Crocco, Elizabeth A;
- Cruchaga, Carlos;
- De Jager, Philip L;
- DeCarli, Charles;
- DeKosky, Steven T;
- Demirci, F Yesim;
- Dick, Malcolm;
- Dickson, Dennis W;
- Doody, Rachelle S;
- Duara, Ranjan;
- Ertekin‐Taner, Nilufer;
- Faber, Kelley M;
- Fairchild, Thomas J;
- Fallon, Kenneth B;
- Farlow, Martin R;
- Ferris, Steven;
- Frosch, Matthew P;
- Galasko, Douglas R;
- Gearing, Marla;
- Geschwind, Daniel H;
- Ghetti, Bernardino;
- Gilbert, John R;
- Glass, Jonathan D;
- Graff‐Radford, Neill R;
- Green, Robert C;
- Growdon, John H;
- Hakonarson, Hakon;
- Hamilton, Ronald L;
- Hardy, John;
- Harrell, Lindy E;
- Head, Elizabeth;
- Honig, Lawrence S;
- Huebinger, Ryan M;
- Huentelman, Matthew J;
- Hulette, Christine M;
- Hyman, Bradley T;
- Jarvik, Gail P;
- Jicha, Gregory A;
- Jin, Lee‐Way;
- Karydas, Anna;
- Kauwe, John SK;
- Kaye, Jeffrey A;
- Kim, Ronald;
- Koo, Edward H;
- Kowall, Neil W;
- Kramer, Joel H;
- LaFerla, Frank M;
- Lah, James J;
- Leverenz, James B;
- Levey, Allan I;
- Li, Ge;
- Lieberman, Andrew P;
- Lin, Chiao‐Feng;
- Lopez, Oscar L;
- Lyketsos, Constantine G;
- Mack, Wendy J;
- Marson, Daniel C;
- Martiniuk, Frank;
- Mash, Deborah C;
- Masliah, Eliezer;
- McCormick, Wayne C;
- McCurry, Susan M;
- McDavid, Andrew N;
- McKee, Ann C;
- Mesulam, Marsel;
- Miller, Bruce L;
- Miller, Carol A;
- Miller, Joshua W;
- Morris, John C;
- Mukherjee, Shubhabrata;
- Murrell, Jill R;
- Myers, Amanda J;
- O'Bryant, Sid;
- Olichney, John M;
- Pankratz, Vernon S;
- Parisi, Joseph E;
- Partch, Amanda;
- Paulson, Henry L;
- Perry, William;
- Peskind, Elaine;
- Petersen, Ronald C;
- Pierce, Aimee;
- Poon, Wayne W;
- Potter, Huntington;
- Quinn, Joseph F;
- Raj, Ashok;
- Raskind, Murray;
- Reisberg, Barry;
- Reisch, Joan S;
- Reitz, Christiane;
- Ringman, John M;
- Roberson, Erik D;
- Rogaeva, Ekaterina;
- Rosen, Howard J;
- Rosenberg, Roger N;
- Royall, Donald R;
- Sager, Mark A;
- Sano, Mary;
- Saykin, Andrew J;
- Schneider, Julie A;
- Schneider, Lon S;
- Seeley, William W;
- Smith, Amanda G;
- Sonnen, Joshua A;
- Spina, Salvatore;
- Stern, Robert A;
- Tanzi, Rudolph E;
- Thornton‐Wells, Tricia A;
- Trojanowski, John Q;
- Troncoso, Juan C;
- Tsuang, Debby W;
- Van Deerlin, Vivianna M;
- Van Eldik, Linda J;
- Vardarajan, Badri N;
- Vinters, Harry V;
- Vonsattel, Jean Paul;
- Weintraub, Sandra;
- Welsh‐Bohmer, Kathleen A;
- Williamson, Jennifer;
- Wishnek, Sarah;
- Woltjer, Randall L;
- Wright, Clinton B;
- Wu, Chuang‐Kuo;
- Yu, Chang‐En;
- Yu, Lei;
- Zhang, Xiaoling;
- Haines, Jonathan;
- Mayeux, Richard;
- Pericak‐Vance, Margaret A;
- Schellenberg, Gerard;
- Lunetta, Kathryn L;
- Farrer, Lindsay A
Published Web Location
https://doi.org/10.1016/j.jalz.2016.12.012Abstract
INTRODUCTION: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. RESULTS: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10-6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10-6). DISCUSSION: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.
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