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Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report

  • Author(s): Ichim, Thomas E
  • Solano, Fabio
  • Lara, Fabian
  • Paris, Eugenia
  • Ugalde, Federico
  • Rodriguez, Jorge
  • Minev, Boris
  • Bogin, Vladimir
  • Ramos, Famela
  • Woods, Erik J
  • Murphy, Michael P
  • Patel, Amit N
  • Harman, Robert J
  • Riordan, Neil H
  • et al.
Abstract

Abstract Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use. We report the case of 29 year old male who suffered a crush fracture of the L1 vertebral body, lacking lower sensorimotor function, being a score A on the ASIA scale. Stem cell therapy comprised of intrathecal administration of allogeneic umbilical cord blood ex-vivo expanded CD34 and umbilical cord matrix MSC was performed 5 months, 8 months, and 14 months after injury. Cell administration was well tolerated with no adverse effects observed. Neuropathic pain subsided from intermittent 10/10 to once a week 3/10 VAS. Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI.

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