- Main
Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.
- Gagliardi, Alessia;
- Porter, Vanessa L;
- Zong, Zusheng;
- Bowlby, Reanne;
- Titmuss, Emma;
- Namirembe, Constance;
- Griner, Nicholas B;
- Petrello, Hilary;
- Bowen, Jay;
- Chan, Simon K;
- Culibrk, Luka;
- Darragh, Teresa M;
- Stoler, Mark H;
- Wright, Thomas C;
- Gesuwan, Patee;
- Dyer, Maureen A;
- Ma, Yussanne;
- Mungall, Karen L;
- Jones, Steven JM;
- Nakisige, Carolyn;
- Novik, Karen;
- Orem, Jackson;
- Origa, Martin;
- Gastier-Foster, Julie M;
- Yarchoan, Robert;
- Casper, Corey;
- Mills, Gordon B;
- Rader, Janet S;
- Ojesina, Akinyemi I;
- Gerhard, Daniela S;
- Mungall, Andrew J;
- Marra, Marco A
- et al.
Published Web Location
https://doi.org/10.1038/s41588-020-0673-7Abstract
Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer genomes, transcriptomes or epigenomes has been performed in this population thus far. We characterized 118 tumors from Ugandan patients, of whom 72 were HIV+, and performed extended mutation analysis on an additional 89 tumors. We detected human papillomavirus (HPV)-clade-specific differences in tumor DNA methylation, promoter- and enhancer-associated histone marks, gene expression and pathway dysregulation. Changes in histone modification at HPV integration events were correlated with upregulation of nearby genes and endogenous retroviruses.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-