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Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

  • Author(s): Fingerlin, TE
  • Murphy, E
  • Zhang, W
  • Peljto, AL
  • Brown, KK
  • Steele, MP
  • Loyd, JE
  • Cosgrove, GP
  • Lynch, D
  • Groshong, S
  • Collard, HR
  • Wolters, PJ
  • Bradford, WZ
  • Kossen, K
  • Seiwert, SD
  • Du Bois, RM
  • Garcia, CK
  • Devine, MS
  • Gudmundsson, G
  • Isaksson, HJ
  • Kaminski, N
  • Zhang, Y
  • Gibson, KF
  • Lancaster, LH
  • Cogan, JD
  • Mason, WR
  • Maher, TM
  • Molyneaux, PL
  • Wells, AU
  • Moffatt, MF
  • Selman, M
  • Pardo, A
  • Kim, DS
  • Crapo, JD
  • Make, BJ
  • Regan, EA
  • Walek, DS
  • Daniel, JJ
  • Kamatani, Y
  • Zelenika, D
  • Smith, K
  • McKean, D
  • Pedersen, BS
  • Talbert, J
  • Kidd, RN
  • Markin, CR
  • Beckman, KB
  • Lathrop, M
  • Schwarz, MI
  • Schwartz, DA
  • et al.

Published Web Location

https://doi.org/10.1038/ng.2609
Abstract

We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (P meta = 2.4 × 10-8 to 1.1 × 10-19), including FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15. Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs. © 2013 Nature America, Inc. All rights reserved.

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