Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.
- Author(s): Ashworth, Alan
- Frankum, J
- Moudry, P
- Brough, R
- Hodny, Z
- Bartek, J
- Lord, CJ
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4484416?pdf=render
Based on a series of basic, preclinical and clinical studies, the Poly (ADP-ribose) Polymerase 1 (PARP1) inhibitor, olaparib, has recently been approved for use in ovarian cancer patients with BRCA1 or BRCA2 mutations. By identifying novel predictive bioma
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