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Dorsal commissural axon guidance in the developing spinal cord.

  • Author(s): Alvarez, Sandy;
  • Varadarajan, Supraja G;
  • Butler, Samantha J
  • et al.
Abstract

Commissural axons have been a key model system for identifying axon guidance signals in vertebrates. This review summarizes the current thinking about the molecular and cellular mechanisms that establish a specific commissural neural circuit: the dI1 neurons in the developing spinal cord. We assess the contribution of long- and short-range signaling while sequentially following the developmental timeline from the birth of dI1 neurons, to the extension of commissural axons first circumferentially and then contralaterally into the ventral funiculus.

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