Dorsal commissural axon guidance in the developing spinal cord.
- Author(s): Alvarez, Sandy;
- Varadarajan, Supraja G;
- Butler, Samantha J
- et al.
Published Web Locationhttps://doi.org/10.1016/bs.ctdb.2020.10.009
Commissural axons have been a key model system for identifying axon guidance signals in vertebrates. This review summarizes the current thinking about the molecular and cellular mechanisms that establish a specific commissural neural circuit: the dI1 neurons in the developing spinal cord. We assess the contribution of long- and short-range signaling while sequentially following the developmental timeline from the birth of dI1 neurons, to the extension of commissural axons first circumferentially and then contralaterally into the ventral funiculus.