Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress
- Author(s): Walter, Peter
- Gallagher, CM
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4954756?pdf=render
© Gallagher and Walter.The membrane-bound transcription factor ATF6α is activated by proteolysis during endoplasmic reticulum (ER) stress. ATF6α target genes encode foldases, chaperones, and lipid biosynthesis enzymes that increase protein-folding capacity