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Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

  • Author(s): Walter, Peter
  • Gallagher, CM
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4954756?pdf=render
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Abstract

© Gallagher and Walter.The membrane-bound transcription factor ATF6α is activated by proteolysis during endoplasmic reticulum (ER) stress. ATF6α target genes encode foldases, chaperones, and lipid biosynthesis enzymes that increase protein-folding capacity

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