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NF-κB transcriptional activation by TNFaα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1

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© 2015 Vuong et al.Background: The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is required for pro-inflammatory effects of TNFaα. Our previous studies demonstrated that PARP-1 mediates TNFaα-induced NF-κB activation in glia. Here, we evaluated th

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