NF-κB transcriptional activation by TNFaα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1
- Author(s): Swanson, Raymond;
- NULL, NULL
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4670503?pdf=render
© 2015 Vuong et al.Background: The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) is required for pro-inflammatory effects of TNFaα. Our previous studies demonstrated that PARP-1 mediates TNFaα-induced NF-κB activation in glia. Here, we evaluated th