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Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma.

  • Author(s): Rennert, Robert C;
  • Achrol, Achal S;
  • Januszyk, Michael;
  • Kahn, Suzana A;
  • Liu, Tiffany T;
  • Liu, Yi;
  • Sahoo, Debashis;
  • Rodrigues, Melanie;
  • Maan, Zeshaan N;
  • Wong, Victor W;
  • Cheshier, Samuel H;
  • Chang, Steven D;
  • Steinberg, Gary K;
  • Harsh, Griffith R;
  • Gurtner, Geoffrey C
  • et al.

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Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. Stem Cells 2016;34:1702-1707.

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