Multiple Subsets of Brain Tumor Initiating Cells Coexist in Glioblastoma.
- Author(s): Rennert, Robert C;
- Achrol, Achal S;
- Januszyk, Michael;
- Kahn, Suzana A;
- Liu, Tiffany T;
- Liu, Yi;
- Sahoo, Debashis;
- Rodrigues, Melanie;
- Maan, Zeshaan N;
- Wong, Victor W;
- Cheshier, Samuel H;
- Chang, Steven D;
- Steinberg, Gary K;
- Harsh, Griffith R;
- Gurtner, Geoffrey C
- et al.
Published Web Location
https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.2359Abstract
Brain tumor-initiating cells (BTICs) are self-renewing multipotent cells critical for tumor maintenance and growth. Using single-cell microfluidic profiling, we identified multiple subpopulations of BTICs coexisting in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to divergent bulk tissue molecular subtypes. These data suggest BTIC subpopulation heterogeneity as an underlying source of intra-tumoral bulk tissue molecular heterogeneity, and will support future studies into BTIC subpopulation-specific therapies. Stem Cells 2016;34:1702-1707.
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