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A block in the pentose shunt and in a purine degradation pathway interact to produce lethality in Drosophila melanogaster

  • Author(s): Lucchesi, JC;
  • Manning, JE
  • et al.

Null activity alleles of the structural genes for glucose-6-phosphate dehydrogenase and xanthine dehydrogenase in Drosophila melanogaster have no or little measurable effect on the viability of mutant flies. In contrast, double mutant combinations lacking both enzyme activities result in lethality. This observation highlights a physiological interaction between metabolic pathways heretofore considered to be independent. © 1988.

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