UCLA

Rhodexin A is a cardiac glycoside first isolated from the leaves and roots of Rhodea Japonica in 1951, which shown potent activity against leukemia K562 cells (IC50 19 nM). A previous synthesis of rhodexin A has been accomplished by the Jung group. A novel synthetic approach, utilizing a convergent Diels Alder reaction with two optically active fragments deriving from Wieland-Miescher ketone and carvone, is reported. Additionally a novel Lewis acid system was developed and utilized during the synthesis and its further applications are described in Chapter 2.