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Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
- Zheng, Yi;
- Qin, Ling;
- Zacarías, Natalia V Ortiz;
- de Vries, Henk;
- Han, Gye Won;
- Gustavsson, Martin;
- Dabros, Marta;
- Zhao, Chunxia;
- Cherney, Robert J;
- Carter, Percy;
- Stamos, Dean;
- Abagyan, Ruben;
- Cherezov, Vadim;
- Stevens, Raymond C;
- IJzerman, Adriaan P;
- Heitman, Laura H;
- Tebben, Andrew;
- Kufareva, Irina;
- Handel, Tracy M
Published Web Location
https://doi.org/10.1038/nature20605Abstract
The crystal structure of CCR2 chemokine receptor in a complex with two different antagonists—one orthosteric the other allosteric—which functionally cooperate to inhibit CCR2.
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