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Open Access Publications from the University of California

IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic Leukemia

  • Author(s): Muschen, Markus
  • Iacobucci, I
  • Iraci, N
  • Messina, M
  • Lonetti, A
  • Chiaretti, S
  • Valli, E
  • Ferrari, A
  • Papayannidis, C
  • Paoloni, F
  • Vitale, A
  • et al.

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Background: Deletions of IKAROS (IKZF1) frequently occur in B-cell precursor acute lymphoblastic leukemia (B-ALL) but the mechanisms by which they influence pathogenesis are unclear. To address this issue, a cohort of 144 adult B-ALL patients (106 BCR-ABL1

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