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Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1

  • Author(s): Kong, Xiangduo
  • Stephens, Jared
  • Ball, Alexander R.
  • Heale, Jason T.
  • Newkirk, Daniel A.
  • Berns, Michael W.
  • Yokomori, Kyoko
  • et al.
Creative Commons Attribution 4.0 International Public License
Abstract

Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how PARP1 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.

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