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Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells

  • Author(s): Hou, S
  • Choi, JS
  • Chen, KJ
  • Zhang, Y
  • Peng, J
  • Garcia, MA
  • Yu, JH
  • Thakore-Shah, K
  • Ro, T
  • Chen, JF
  • Peyda, P
  • Fan, G
  • Pyle, AD
  • Wang, H
  • Tseng, HR
  • et al.
Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.

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