Skip to main content
eScholarship
Open Access Publications from the University of California

Effects of pair bonding on dopamine D1 receptors in monogamous male titi monkeys (Callicebus cupreus)

  • Author(s): Hostetler, CM
  • Hinde, K
  • Maninger, N
  • Mendoza, SP
  • Mason, WA
  • Rowland, DJ
  • Wang, GB
  • Kukis, D
  • Cherry, SR
  • Bales, KL
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pubmed/27757971
No data is associated with this publication.
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License
Abstract

© 2016 Wiley Periodicals, Inc. Pair bonding leads to increases in dopamine D1 receptor (D1R) binding in the nucleus accumbens of monogamous prairie voles. In the current study, we hypothesized that there is similar up-regulation of D1R in a monogamous primate, the titi monkey (Callicebus cupreus). Receptor binding of the D1R antagonist [11C]-SCH23390 was measured in male titi monkeys using PET scans before and after pairing with a female. We found that within-subject analyses of pairing show significant increases in D1R binding in the lateral septum, but not the nucleus accumbens, caudate, putamen, or ventral pallidum. The lateral septum is involved in a number of processes that may contribute to social behavior, including motivation, affect, reward, and reinforcement. This region also plays a role in pair bonding and paternal behavior in voles. Our observations of changes in D1R in the lateral septum, but not the nucleus accumbens, suggest that there may be broadly similar dopaminergic mechanisms underlying pair bonding across mammalian species, but that the specific changes to neural circuitry differ. This study is the first research to demonstrate neuroplasticity of the dopamine system following pair bonding in a non-human primate; however, substantial variability in the response to pairing suggests the utility of further research on the topic.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item