Endoplasmic reticulum calcium, stress, and cell-to-cell adhesion.
- Author(s): Mauro, Theodora
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4083462?pdf=render
Darier's disease (DD) is caused by mutations in the endoplasmic reticulum (ER) Ca2+ ATPase ATP2A2 (protein SERCA2). Current treatment modalities are ineffective for many patients. This report shows that impaired SERCA2 function, both in DD keratinocytes an
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