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A new therapeutic target for myelofibrosis is cause for Gli.
Published Web Location
https://doi.org/10.1126/scitranslmed.aan4297Abstract
Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor.
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