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Open Access Publications from the University of California

SAPHO syndrome: the value of classic drugs in the era of biologics

  • Author(s): Gil, Francisco
  • Mariano, Paulina
  • Silva, Soraia
  • Gil, José
  • Eufémia Calmeiro, Maria
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

SAPHO syndrome is a rare entity, composed of dermatologic and osteoarticular manifestations. There are no validated diagnostic criteria and treatment is empirical, with a recent focus on biologics. Herein, we present a 50-year-old woman who developed palmoplantar pustulosis and sternoclavicular osteitis, with typical findings on bone scintigraphy. Treatment with bisphosphonate, low-dose systemic corticosteroid, and cyclosporine allowed complete resolution of the articular and dermatologic manifestations with no side effects.

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