Skip to main content
Open Access Publications from the University of California


UCLA Previously Published Works bannerUCLA

Influence of Sulfoxide Group Placement on Polypeptide Conformational Stability.

  • Author(s): Gharakhanian, Eric G
  • Bahrun, Ehab
  • Deming, Timothy J
  • et al.

The synthesis of a homologous series containing five new nonionic sulfoxide containing polypeptides was described. Sulfoxide groups bestowed water solubility for all homologues, which allowed their use as a model for study of helix-coil transitions in water while avoiding contributions from charged groups or phase separation. Polypeptides were found to adopt chain conformations in water that were dependent on distance of sulfoxides from chain backbones, overall side-chain lengths, and solvent. These results allow preparation of polypeptide segments with different chain conformations without changing chemical functionality for potential use in structural studies and functional applications.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View