Influence of Sulfoxide Group Placement on Polypeptide Conformational Stability.
- Author(s): Gharakhanian, Eric G
- Bahrun, Ehab
- Deming, Timothy J
- et al.
Published Web Locationhttps://doi.org/10.1021/jacs.9b07223
The synthesis of a homologous series containing five new nonionic sulfoxide containing polypeptides was described. Sulfoxide groups bestowed water solubility for all homologues, which allowed their use as a model for study of helix-coil transitions in water while avoiding contributions from charged groups or phase separation. Polypeptides were found to adopt chain conformations in water that were dependent on distance of sulfoxides from chain backbones, overall side-chain lengths, and solvent. These results allow preparation of polypeptide segments with different chain conformations without changing chemical functionality for potential use in structural studies and functional applications.