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Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment

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https://doi.org/10.1080/23723556.2021.1994328
Abstract

In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that affect EGFR-driven lung tumor growth and sensitivity to tyrosine kinase inhibitors and reflect the mutational landscape and treatment outcomes in the human disease.

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