UCSF

Purpose

To validate the potential of quantifying R₂ -R_1ρ using one pair of signals with T_1ρ preparation and T₂ preparation incorporated to magnetization-prepared angle-modulated partitioned k-space spoiled gradient-echo snapshots (MAPSS) acquisition and to find an optimal preparation time (T_prep ) for in vivo knee MRI.

Methods

Bloch equation simulations were first performed to assess the accuracy of quantifying R₂ -R_1ρ using T_1ρ - and T₂ -prepared signals with an equivalent T_prep . For validation of this technique in comparison to the conventional approach that calculates R₂ -R_1ρ after estimating both T₂ and T_1ρ , phantom experiments and in vivo validation with five healthy subjects and five osteoarthritis patients were performed at a clinical 3T scanner.

Results

Bloch equation simulations demonstrated that the accuracy of this efficient R₂ -R_1ρ quantification method and the optimal T_prep can be affected by image signal-to-noise ratio (SNR) and tissue relaxation times, but quantification can be closest to the reference with an around 25 ms T_prep for knee cartilage. Phantom experiments demonstrated that the proposed method can depict R₂ -R_1ρ changes with agarose gel concentration. With in vivo data, significant correlation was observed between cartilage R₂ -R_1ρ measured from the conventional and the proposed methods, and a T_prep of 25.6 ms provided the most agreement by Bland-Altman analysis. R₂ -R_1ρ was significantly lower in patients than in healthy subjects for most cartilage compartments.

Conclusion

As a potential biomarker to indicate cartilage degeneration, R₂ -R_1ρ can be efficiently measured using one pair of T_1ρ -prepared and T₂ -prepared signals with an optimal T_prep considering cartilage relaxation times and image SNR.