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Open Access Publications from the University of California

Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer

  • Author(s): Collisson, Eric
  • Korkola, JE
  • Collisson, EA
  • Heiser, L
  • Oates, C
  • Bayani, N
  • Itani, S
  • Esch, A
  • Thompson, W
  • Griffith, OL
  • Wang, NJ
  • et al.

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© 2015 Korkola et al.We report here on experimental and theoretical efforts to determine how best to combine drugs that inhibit HER2 and AKT in HER2+ breast cancers. We accomplished this by measuring cellular and molecular responses to lapatinib

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