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Open Access Publications from the University of California

Polymorphism in the Androgen Receptor and Mammographic Density in Women Taking and Not Taking Estrogen and Progestin Therapy

  • Author(s): Lillie, Elizabeth Osth;
  • Bernstein, Leslie;
  • Ingles, Sue Ann;
  • Gauderman, W James;
  • Rivas, Guillermo E;
  • Gagalang, Virgilio;
  • Krontiris, Theodore;
  • Ursin, Giske
  • et al.
Abstract

There is some evidence that women with a higher number of CAG repeat lengths on the androgen receptor (AR) gene have increased breast cancer risk. We evaluated the association between AR-CAG repeat length and mammographic density, a strong breast cancer risk factor, in 404 African-American and Caucasian breast cancer patients. In postmenopausal estrogen progestin therapy users, carriers of the less active AR-CAG had statistically significantly higher mean percentage of density (41.4%) than carriers of the more active AR-CAG (25.7%; P = 0.04). Our results raise the question of whether the number of AR-CAG repeats predicts breast cancer risk in estrogen progestin therapy users.

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