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Do All Roads Lead to Rome in G-Protein Activation?
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https://doi.org/10.1016/j.tibs.2019.10.010Abstract
High-resolution structural studies on G-protein-coupled receptors (GPCRs) have flourished recently, providing long-sought insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activation. In parallel, analogous studies are starting to shed light on how the same G-proteins are activated by non-GPCR proteins. Can we learn about common themes and variations in G-protein activation from them?
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