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Open Access Publications from the University of California

The pesticide reregistration process: Collections of human health hazards data for 3-chloro-p-toluidine hydrochloride (DRC-1339)


The 1988 Amendments to the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) accelerated the reregistration schedule for pesticide products registered with the Environmental Protection Agency (EPA) prior to 1984. The compound 3-chloro-p-toluidine hydrochloride (DRC-1339), an avicide registered to control 14 pest bird species, was included on Pesticide List B published by EPA. For the reregistration of DRC-1339, 44 studies were required− 22 product chemistry, 7 wildlife/aquatic hazards, 8 human/domestic animal hazards, 5 environmental fate, and 2 residue chemistry studies. In 5 acute human-health-hazards studies, DRC-1339 was found to: (1) have an oral LD50 of 330 (272-401) mg/kg in rats, (2) have a dermal LD50 of >2.0 g/kg in rabbits, (3) cause corrosive effects to the eyes of rabbits, (4) cause corrosive effects to the skin of rabbits, and (5) induce dermal sensitization in guinea pigs. Results support the current precautionary statements on the "use labels" warning of harmful ingestion, inhalation, dermal absorption and eye irritation effects to users of the active ingredient.

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