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Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins

Published Web Location

https://doi.org/10.1128/jvi.03060-15
Abstract

A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

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