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Open Access Publications from the University of California

Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Macaca mulatta) with Seizures.

  • Author(s): Li, Chun-Xia
  • Kempf, Doty J
  • Tong, Frank C
  • Yan, Yumei
  • Xu, Zhengfeng
  • Connor-Stroud, Fawn R
  • Ford, Byron D
  • Howell, Leonard L
  • Zhang, Xiaodong
  • et al.

An adult rhesus macaque developed seizures after the induction of ischemic stroke. Initially, on the day of surgery, a focalischemic lesion was present exclusively in the right caudate nucleus. By 48 h after stroke induction, the lesion had extendedinto the putamen, when a seizure was observed. Our report highlights the temporal changes in infarction of unilateral basalganglia after acute stroke and the accompanying clinical symptoms. This unusual case may provide additional informationregarding the involvement of the basal ganglia in seizures, given that prior case reports and studies usually have not describedthe temporal and spatial evolution of the lesion before clinical symptoms emerge.

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