Skip to main content
eScholarship
Open Access Publications from the University of California

UCLA

UCLA Previously Published Works bannerUCLA

Electric field-catalyzed single-molecule Diels-Alder reaction dynamics.

  • Author(s): Yang, Chen;
  • Liu, Zitong;
  • Li, Yanwei;
  • Zhou, Shuyao;
  • Lu, Chenxi;
  • Guo, Yilin;
  • Ramirez, Melissa;
  • Zhang, Qingzhu;
  • Li, Yu;
  • Liu, Zhirong;
  • Houk, KN;
  • Zhang, Deqing;
  • Guo, Xuefeng
  • et al.
Abstract

Precise time trajectories and detailed reaction pathways of the Diels-Alder reaction were directly observed using accurate single-molecule detection on an in situ label-free single-molecule electrical detection platform. This study demonstrates the well-accepted concerted mechanism and clarifies the role of charge transfer complexes with endo or exo configurations on the reaction path. An unprecedented stepwise pathway was verified at high temperatures in a high-voltage electric field. Experiments and theoretical results revealed an electric field-catalyzed mechanism that shows the presence of a zwitterionic intermediate with one bond formation and variation of concerted and stepwise reactions by the strength of the electric field, thus establishing a previously unidentified approach for mechanistic control by electric field catalysis.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View