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Health state utility valuation in radioactive iodine-refractory differentiated thyroid cancer.
- Author(s): Fordham, Beth A;
- Kerr, Cicely;
- de Freitas, Hayley M;
- Lloyd, Andrew J;
- Johnston, Karissa;
- Pelletier, Corey L;
- Tremblay, Gabriel;
- Forsythe, Anna;
- McIver, Bryan;
- Cohen, Ezra Ew
- et al.
Published Web Locationhttps://doi.org/10.2147/ppa.s90425
PurposeThe aim of this study was to elicit utilities for radioactive iodine-refractory differentiated thyroid cancer (RR-DTC) and evaluate the impact of treatment response and toxicities on quality of life.
Patients and methodsRR-DTC health states were developed based on data from a previous qualitative study and iterative review by clinical experts. Following piloting, health states underwent valuation by 100 members of the UK public during time trade-off interviews. Mean utilities and descriptive distribution statistics were calculated, and a logistic regression analysis was conducted.
ResultsThe demographic characteristics of the study sample were generally reflective of the UK population. Clear differentiation in valuation between health states was observed. No response/stable disease had an adjusted utility value of 0.87, with a corresponding gain of +0.04 following a treatment response and a decline of -0.35 for disease progression. Adverse events were associated with utility decrements between -0.47 (grade III diarrhea) and -0.05 (grade I/II alopecia).
ConclusionThe trade-off interviews derived utility weights show clear differentiation between RR-DTC health states in response to treatment. The values reported in this study are suitable for cost-effectiveness evaluations for new treatments in RR-DTC.
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